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The effect of Cassia fistula L. syrup in geriatrics constipation in comparison with the lactulose: A randomized clinical trial, 2022 -

The effect of Cassia fistula L. syrup in geriatrics constipation in comparison with the lactulose: A randomized clinical trial, 2022

تاثیر شربت فلوبل(عصاره آبی فلوس) در یبوست سالمندان در مقایسه با لاکتوز: یک کارآزمایی بالینی تصادفی شده


PDF(The effect of Cassia fistula L. syrup in geriatrics constipation in comparison with the lactose: A Randomized clinical trial)

Farangiz Sepehr, Hoda Shirafkan, Catherine Behzad, Zahra Memariani, Seyyed Ali Mozaffarpur

چکیده:

فارماکولوژیک: گیاه فلوس (Cassia fistula) در طب سنتی ایرانی به عنوان ملین ملایم کاربرد فراوانی دارد. میزان یبوست مزمن در سن بالای 60 سال افزایش می­یابد.

هدف: این مطالعه با هدف بررسی تاثیر شربت فلوبل(فلوس) (Cassia fistula) بر یبوست سالمندان انجام شد.

مواد و روش­ها: این مطالعه کارآزمایی بالینی بر روی 70 بیمار سالمند مراجعه کننده به کلینیک گوارش بیمارستان روحانی بابل، شمال ایران انجام شد. بیماران به طور تصادفی به دو گروه: شربت فلوبل(Cassia fistula) و لاکتوز با دوز 30 سی­سی در روز تقسیم شدند. بیماران 2 هفته پس از ورود بررسی دفع، احساس تخلیه ناقص پس از اجابت مزاج، مانور دستی، قوام مدفوع و همچنین کیفیت زندگی ویزیت شدند.

نتایج: فراوانی دفع مدفوع در هفته از 1/16 ± 1/82 تا 3/44 ± 8/36 در گروه شربت فلوبل(Cassia fistula) پس از 2 هفته مداخله متغییر بود که به طور قابل توجهی بیشتر از لاکتوز بود که از 1/46 ± 2/16 به 2/96 ± 5/66 تغییر کرد. کیفیت زندگی، درصد زور زدن، مدفوع توده یا سفت، درد در هنگام اجابت مزاج و قوام مدفوع بر اساس VASدر گروه شربت فلوبل به طور معنی­داری بهتر بود.

نتیجه­ گیری: شربت فلوبل(فلوس) می­تواند موثرتر از لاکتوز بر روی یبوست سالمندان باشد.

Abstract

Ethnopharmacological relevance: Cassia fistula is widely used in traditional Persian Medicine as a
mild laxative. The rate of chronic constipation increases above the age of 60.

Aim of the study: This study aimed to investigate the effect of Cassia fistula syrup (CFS) on geriatric
constipation.

Materials and methods: This clinical trial study was performed on 70 aged patients who were
referred to the clinic of gastroenterology of Rouhani Hospital, Babol, North of Iran. Patients were
randomly divided into two groups of CFS or Lactulose with a dose of 30 ccs/day. Patients were visited
two weeks after entering the study to evaluate the frequency of defecation, feeling of incomplete
emptying after defecation, manual maneuver, consistency of stool, and also the quality of life.

Results: The frequency of defecation per week varied from 1.82 ± 1.16 to 8.36 ± 3.44 in the CFS group
after 2 weeks of intervention that was significantly more than the Lactulose that changed from 2.16 ±
1.46 to 5.66 ± 2.96 (P-value = 0.023, partial eta square = 0.079, NNT = 4). The quality of life, the
percent of straining, lumpy or hard stool, pain during defecation, and the consistency of stool based
on VAS were significantly better in the CFS group. The sensation of incomplete defecation, anorectal
obstruction, and manual maneuvering were not different significantly between groups.

Conclusion: CFS can be more effective than Lactulose on geriatric constipation.

سبد خرید
پیمایش به بالا

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